Project title: Characterization of extracellular vesicles for early detection of neuroendocrine tumors
Tijana Jovanovic-Talisman, PhD Beckman Research Institute of the City of Hope
- Status: Active
- Year(s): 2025
- Grant Type: Pilot
- Research Type: Translational
- Primary Tumor Site: Other
- Area of Inquiry: Diagnostic, Biomarkers
What critical NET problem/question will researchers try to answer?
Because NETs can grow slowly and cause vague symptoms like pain or diarrhea, they are often detected very late, when surgery as a curative treatment is no longer possible. To improve outcomes, earlier and more accurate detection is urgently needed. We are trying to find more opportunities for early detection.
Why is this important?
To improve outcomes, earlier and more accurate detection is urgently needed. Our goal is to develop a blood-based assay to detect neuroendocrine cancers earlier.
What will the researchers do?
Tumor cells release tiny particles, called extracellular vesicles (EVs), into the bloodstream. These vesicles carry unique “fingerprints” that reveal their tumor origin. Using cutting-edge microscopes and machine learning, the team has already shown it is possible to capture part of this fingerprint in patient samples. The next step is to refine this technology in a larger group of patients, improving its ability to detect tumor-specific vesicles with high sensitivity and accuracy.
How might this improve the treatment of NETs?
Early detection and intervention can significantly improve outcomes for patients with neuroendocrine cancers.
Additional Details
- City: Duarte
- State: CA
- Country: United States
- Grant Duration: 1 year
- Sponsor: Laura and Lew Moorman
DISCLAIMER
NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.