Project title Researcher(s)

An integrated preclinical and clinical evaluation of DNA-repair mechanisms in determining response to PRRT as a guide to patient selection and for development of novel combination therapies

Rodney Hicks, MD

Epigenetic regulators of intestinal endocrine cells and carcinoid tumors

Qiao Zhou, PhD; Ramesh Shivdasani, MD, PhD

Finding the causes of small intestinal neuroendocrine tumors

Matthew Meyerson, MD, PhD; Eric Nakakura, MD, PhD; Chrissie Thirlwell, MD, PhD

Mesenteric fibrosis in small intestinal neuroendocrine tumors: pathogenesis

Martyn Caplin, DM, FRCP

Modeling NETs using adult stem cell-derived organoids

Hans Clevers, MD, PhD

Multipronged approaches to develop immunotherapy targeting NETs

Xianxin Hua, MD, PhD

PANNET Modeling, Mechanisms, and Experimental Treatment

James Bibb, PhD

The role of the B7x pathway in the progression of NETs

Steven K Libutti, MD