Project title: Defining the immune landscape of neuroendocrine tumors in response to conventional treatment – towards rational combination therapy
Tim Meyer, MD, PhD UCL Cancer Institute, University College London
- Status: Completed
- Year(s): 2016
- Grant Type: Investigator
- Research Type: Translational
- Primary Tumor Site: Small intestine
- Area of Inquiry: Immune environment
General Description
Immunotherapy is being explored in many tumor types with encouraging results, but there is limited investigation of this modality for patients with NET. In this project, we will characterize the immune-landscape in NET and investigate the effect of therapy on the immune cell tumor infiltration. We will also determine which relevant immune-modulatory pathways control the function of tumor-infiltrating lymphocytes. We anticipate the data generated will guide a rational approach for combination immunotherapy for patients with NET and improve outcomes for patients.Additional Details
- Grant Duration: 2 years
- Awards: No information
DISCLAIMER
NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.