Project title: Understanding the physiologically relevant functions of DAXX
Guillermina (Gigi) Lozano, PhD MD Anderson Cancer Center
- Status: Completed
- Year(s): 2018
- Grant Type: Investigator
- Research Type: Basic
- Primary Tumor Site: Small intestine
- Area of Inquiry: Models
- Article/Video: Click Here
General Description
To build upon an earlier discovery made by NETRF-funded research, investigators will explore the role of DAXX genomic mutations in pancreatic NETs. First, researchers will study the normal functions of the DAXX gene in laboratory models, then evaluate what happens when the gene is removed. This knowledge can help to identify therapeutic targets.
Published Papers
Wasylishen AR, Sun C, Moyer SM, et al. DAXX maintains endogenous retroviral silencing and restricts cellular spasticity in vivo. Sci Adv. 2020; 6(32):eaba8415.
Additional Details
- City: Houston
- State: Texas
- Grant Duration: 2 years
DISCLAIMER
NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.