Project title: The impact of MEN1, DAXX, ATRX, and PTEN in pancreatic neuroendocrine cancer pathogenesis

Kwok-Kin Wong, MD, PhD Dana-Farber Cancer Institute

Kwok-Kin Wong, MD, PhD
  • Status: Completed
  • Year(s): 2012
  • Research Type: Basic
  • Primary Tumor Site: Pancreas
  • Area of Inquiry: Models

General Desription

In this projec,t Dr. Wong will create the mouse models necessary to determine the impact of recently identified mutations in neuroendocrine tumor development. Next Dr. Wong will conduct experiments using his mouse models to identify the cellular pathways that are deregulated as a result of these mutations. Any pathways identified represent potentially new and novel therapeutic targets for treatment of patients with neuroendocrine tumors. The roles of several genes found to be frequently mutated in non-familial pancreatic neuroendocrine cancer are mostly unknown. In this project, Dr. Wong’s laboratory will introduce these mutations specifically in mouse pancreatic cells and study how these mutations might cause neuroendocrine tumors to develop.


Additional Details

  • City: Boston
  • State: Massachusetts
  • Grant Duration: 2 years
  • Awards: No information


NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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