Project title: Octreotide-targeted treatment of pancreatic NETs

Renata Pasqualini, PhD MD Anderson Cancer Center

Renata Pasqualini, PhD
  • Status: Completed
  • Year(s): 2011
  • Grant Type: Collaborative
  • Research Type: Translational
  • Primary Site: Pancreas
  • Area of Inquiry: Vaccine/virus

General Description

This study aims to utilize SSTR2 receptors present on pancreatic NETs to target and deliver therapeutic agents directly to the tumors themselves. Researchers will first design a virus containing octreotide on its protein surface, which will allow the virus to bind to cells containing SSTR2 receptors (i.e. pancreatic NETs). The virus will contain the gene for TNF-a, a protein that induces cell inflammation and death. The intended goal is that the virus will selectively target pancreatic NETs via the SSTR2 receptor, deliver the TNF-a gene, and in tum cause cell death without harming surrounding healthy cells. The successful completion of this study will address the lack of a gene therapy approach to the treatment of pancreatic NETs.

Publication

Smith TL, Yuan Z,  Cardó-Vila M, Claros S, Adem A, Cui MH, Branch CA, Gelovani JG, Libutti SK,  Sidman RL, Pasqualini R, Arap W. AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas. Proc Natl Acad Sci U S A. 2016 Mar 1; 113(9): 2466–2471. Published online 2016 Feb 16. doi: 10.1073/pnas.1525709113

Additional Details

  • City: Houston
  • Grant Duration: 2 years
  • Grant Partner: American Association for Cancer Research (AACR)
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