Project title: Mouse model project using forward genetics (2012)

David Tuveson, MD, PhD Cold Spring Harbor Laboratory

David Tuveson, MD, PhD
  • Status: Completed
  • Year(s): 2012
  • Research Type: Basic
  • Primary Tumor Site: Small intestine
  • Area of Inquiry: Models

General Description

Dr. Tuveson’s laboratory will use their expertise in forward genetics and mouse cancer modeling to mutagenize enterochromaffin cells, enteroendocrine cells found in the digestive and respiratory tracts, to both generate models of carcinoid cancer and simultaneously identify genes and pathways that promote carcinoid cancer formation.

The lack of model systems that accurately recapitulate the behavior of neuroendocrine cancers has long been a significant hurdle to developing targeted treatments for patients. This project has the promise to create faithful animal models; therefore, eliminating one of the barriers to treatment development.


Additional Details

  • Grant Duration: 2 years
  • Awards: No information


NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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