Project title: Modeling to predict benefit of PRRT in NET patients
Victor Santoro Fernandes, PhD University of Wisconsin
- Status: Active
- Year(s): 2024
- Grant Type: Investigator
- Research Type: Clinical
- Primary Tumor Site: Multiple
- Area of Inquiry: Theranostics, Imaging, PET, PRRT
Description
What critical NET problem/question will researchers try to answer?
My research seeks to address a critical challenge in neuroendocrine tumors (NETs) – improving the prediction of patient benefit from peptide receptor radionuclide therapy (PRRT). Current approaches do not adequately differentiate patients who will benefit from PRRT, leading to potential ineffective treatment and unnecessary side effects.
Why is this important?
Developing a robust and comprehensive modeling approach to predict outcomes in NET patients receiving PRRT could significantly improve clinical management. By avoiding ineffective treatment delivery and minimizing side effects, this research has the potential to personalize therapy and enhance patient outcomes. Furthermore, it could help inform trial designs for underserved populations, such as those with lung NETs, rare NETs, or patients requiring retreatment.
What will the researchers do?
This project centers on developing and refining predictive data models for PRRT outcomes. This involves using advanced methodologies to identify patients likely to experience high benefit from PRRT and those who may need alternative approaches. The project will leverage data from large trials such as NETTER-1 and NETTER-2 to validate and optimize these models.
How might this improve the treatment of NETs?
This work could lead to a paradigm shift in the management of NETs. By allowing better patient selection for PRRT, clinicians could improve treatment efficacy, reduce adverse effects, and design more personalized approaches for underserved populations. The ability to tailor treatment based on predicted outcomes could greatly enhance both the quality and duration of patient survival.
Additional Details
- City: Madison
- State: Wisconsin
- Country: United States
- Grant Duration: 2 years
DISCLAIMER
NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.