Project title: Models of NETs using 3D hydrogels

Charlotte Kuperwasser, PhD Tufts University Medical School

Charlotte Kuperwasser, PhD
  • Status: Completed
  • Year(s): 2018
  • Grant Type: Pilot
  • Research Type: Basic
  • Primary Tumor Site: Small intestine
  • Area of Inquiry: Models

General Description

This one-year Pilot Project will aim to develop a new experimental model that can be used to study NET formation and progression. Using 3D hydrogel technology developed in the Piyush Gupta lab at Whitehead Institute — that allows other tumors isolated from patients to grow with greater than 90 percent success — Kuperwasser, Gupta, and colleagues will apply this technique to grow ileum and appendix NETs. The researchers will use this experimental model to understand how NETs grow inside the intestine or the appendix and will try to establish NET cell lines that could ultimately be used to assess therapeutic response.  

Additional Details

  • City: Boston
  • State: Massachusetts
  • Grant Duration: 1 years
  • Awards: Pilot Project


NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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