Project title: Generate mouse models of neuroendocrine cancer

Seung Kim, MD, PhD Stanford University

Seung Kim, MD, PhD
  • Status: Completed
  • Year(s): 2006
  • Research Type: Basic
  • Primary Tumor Site: Small intestine
  • Area of Inquiry: Models

General Description

Researchers will generate mouse models of carcinoid using conditional genetics. These mouse lines will permit investigation of tumor pathogenesis and create tumor-derived cell lines. Collectively these novel reagents will facilitate genomic, physiologic, and pharmacologic studies of carcinoid.


Dr. Kim explored the use of mice to reconstruct tumors resembling carcinoids with a goal to produce a carcinoid cell line. His strategy was based on prior successful creation of tumors and tumor cell lines from a variety of mouse hormonal cells in the intestines and pancreas. He used a genetic approach based on the idea that carcinoid likely originates from specific intestinal cells producing the TPH gene. Thus far, Dr. Kim has not produced useful tumors or tumor cell lines resembling carcinoid but is continuing this approach, even after cessation of funding from  NETRF.


Additional Details

  • State: California
  • Grant Duration: 2 years
  • Awards: No information


NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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