Project title: Exploring the role of epigenetic dysregulation in PanNET progression

Sita Kugel, PhD Fred Hutchinson Cancer Research Center

Sita Kugel, PhD
  • Status: Completed
  • Year(s): 2018
  • Grant Type: Pilot
  • Research Type: Basic
  • Primary Tumor Site: Pancreas
  • Area of Inquiry: Mapping NET dependencies

General Description

This one-year Pilot Project will investigate how pancreatic neuroendocrine tumors (PanNETs) spread to other organs in the body. Kugel and colleagues have found that a protein called SIRT6 plays a role in metastasis in PanNETs, in pre-clinical models. The investigators hypothesize that loss of SIRT6 may affect metastatic progression in PanNETs. To test this, they will block SIRT6 to see if tumor cells grow faster in its absence, which would suggest that SIRT6 may block metastasis. Their findings could inform the pursuit of targeted therapies, which could help stop the spread of PanNETs.


Additional Details

  • City: Seattle
  • State: Washington
  • Grant Duration: 1 year
  • Awards: Pilot Project
  • Sponsor: Margie & Robert E. Petersen Foundation


NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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