Project title: Epigenetic dysregulation of transposons in pancreatic neuroendocrine tumors

Parijat Senapati, PhD Beckman Research Institute of the City of Hope

Parijat Senapati, PhD
  • Status: Active
  • Year(s): 2020
  • Grant Type: Mentored
  • Research Type: Basic
  • Primary Tumor Site: Pancreas
  • Area of Inquiry: Deciphering the molecular underpinnings of NETs

Description 

Senapati is researching whether defects in the ATRX and DAXX genes activate certain sequences in DNA that cause pancreatic NETs to form. She is also studying changes in DNA methylation to find elements that may be activated in the formation of tumors. 

What question will you try to answer through your research?

My study will address which genetic components, called retrotransposons, are expressed in pancreatic NETs (PNETs) that have mutations in the ATRX and DAXX genes, and whether an abnormal expression of retrotransposon proteins can help predict outcomes for patients. My team and I will also explore how the ATRX/DAXX mutation in PNETs leads to dysregulation of retrotransposons that are silenced and tightly regulated in normal cells.

Why is this important?

ATRX/DAXX mutations in PNETs are associated with a worse prognosis for patients. If we better understand which retrotransposons are abnormally regulated in PNETs and how they lead to cancer progression, we may be able to identify markers that may affect prognosis and develop new treatment strategies for PNETs.

What will you do as part of this research project?

We will analyze the abnormal genomes of PNETs and the aberrant regulation of their genetic components that contribute to the formation of PNETs. We will explore the role and contribution of the ATRX and DAXX genetic mutations in causing pancreatic NETs. 

How might your research improve the treatment of NETs?

This study will help us identify genes and genetic pathways that may be used to develop diagnostic or prognostic markers and immunotherapeutic strategies to target PNETs. 

What is your next step?

Our study will explore whether the expression of retrotransposon proteins is associated with poorer clinical outcomes. The results may point to possible therapeutic strategies that target these proteins in PNETs.

Additional Details

  • City: Duarte
  • State: California
  • Country: United States
  • Grant Duration: 2 years
  • Awards: Mentored
  • Sponsor: Ipsen Biopharmaceuticals

DISCLAIMER

NETRF funds laboratory research to understand the development of neuroendocrine tumors and translational research to explore new concepts in treatment. Research grant descriptions and research updates from NETRF are not intended to serve as medical advice. It can take years for research discoveries to be fully validated and approved for patient care. Always consult your health care providers about your treatment options.

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