Project title: Characterization of supra-carcinoids cell states to inform interception strategies

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What critical neuroendocrine cancer problem/question will researchers try to answer?
This project aims to reveal the hidden characteristics of the most aggressive form of lung neuroendocrine tumors, supra-carcinoids, to advance their clinical management and ultimately improve patient prognosis

Why is this important?
Supra-carcinoids, a rare subtype of lung NETs, may only represent a small fraction of cases, but they account for a disproportionately high number of relapses and deaths. Currently, supra-carcinoids aren’t even recognized as a formal diagnosis in the WHO classification system, which means patients are often misclassified and missed. 

What will the researchers do?
We aim to uncover the biological mechanisms that drive the aggressiveness of supra-carcinoids, developing biomarkers to predict recurrence, and creating tools for accurate diagnosis and targeted treatment.

How might this improve the treatment of neuroendocrine cancer?
By identifying these tumors early, we can better manage the most severe cases, potentially spare low-risk patients years of monitoring, and direct therapies where they are most needed. Beyond improving care for these patients, this research will provide a blueprint for understanding how cancers ‘flip the switch’ from indolent to aggressive. This knowledge could have a far-reaching impact across oncology.  

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