Project title: An improved approach for detection and therapeutic monitoring of neuroendocrine tumors by PET

Babak Behnam Azad, PhD Johns Hopkins School of Medicine, Baltimore

Babak Behnam Azad, PhD
  • Status: Active
  • Year(s): 2017
  • Grant Type: Collaborative
  • Research Type: Clinical
  • Primary Tumor Site: Pancreas/small intestine
  • Area of Inquiry: Diagnostic

General Description

The study evaluates a novel strategy for the direct, non-invasive imaging of NETS by PET, which is currently the most sensitive clinical imaging technique. This approach will circumvent the limitations of [18F]Flouro-L-DOPA, a well-studied tracer for clinical applications, with the development of novel tracer element, (18F) FLuoro-D-DOPA . The study assesses the enzymatically more stable FDOPA isomer, [18F]Fluoro-D-DOPA, for non-invasive in vivo detection of NETs by PET. This study will provide the first evaluation of this tracer for NET imaging and the first comprehensive side-by-side evaluation of [18F]Fluoro-L-DOPA and [18F]Fluoro-D-DOPA in any disease model. Accumulating literature have suggested LAT1 as a viable diagnostic and prognostic marker,thereby prompting the development of LAT1-targeted imaging agents and therapeutics.The amino acid 3,4-L-dihydroxyphenylalanine (L-DOPA) is transported to the cytoplasm of neuroendocrine cells by LAT1, where it is metabolized to dopamine, noradrenaline and adrenaline.  

Additional Details

  • Grant Duration: 1 years
  • Grant Partner: Education and Research Foundation for Nuclear Medicine and Molecular Imaging
  • Awards: NETRF/ERF Nuclear Medicine Pilot Research Grant
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