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A research position for a postdoctoral fellow or experienced researcher is now available at the University of Alabama Birmingham Medical Center within the basic, translational, and preclinical research program to study overlapping mechanisms of disease in neuroendocrine cancer and the brain.

Projects include understanding the integration of fast and slow neurotransmission as it pertains to neurological and neuropsychiatric diseases including mental illness, drug addiction, gut-brain comorbidity, chemobrain, and neuronal injury. Each of these projects incorporates experimental therapeutic intervention. Multidisciplinary techniques include in vivo photometric and single unit slice recording, optogenetics, single cell multi-omic analysis, pharmacology, histology, intracellular signal transduction analysis. The successful candidate will join a multidisciplinary team of biochemists, behaviorists, physiologists, and neuropathologists within the setting of a strong cores providing capabilities in neurophysiology, imaging, behavioral, bioinformatic, and other advanced approaches. An overall goal of this research is to understand the mechanisms that dictate normal brain function and their maladaptation in disease. The successful candidate will work both independently and as part of a team aimed at making advances and publishing high impact work. Several projects are well developed so that clear existing data can be used to rapidly demonstrate productivity. The incorporation of multiple perspectives and advanced technologies is a hallmark of this sustained and well-funded research program and will provide the applicant with the opportunity to produce high impact publications and establish a strong record of grant award funding. The candidate will receive committed mentoring and career development toward independent research and training to become a principal investigator.

Enthusiastic applicants with a Ph.D. and several years of experience in neurobiology, physiology, biochemistry, molecular pharmacology, or multi-omic analyses are strongly encouraged to apply by submitting their C.V. and 3 references to Dr. James Bibb, jbibb@uab.edu.

UAB features a large clinical and scientific community with a world-renowned faculty and has state-of-the-art research facilities. UAB is an equal opportunity employer.

A research position for a postdoctoral fellow or experienced researcher is now available at the University of Alabama Birmingham Medical Center within the basic, translational, and preclinical research program to study overlapping mechanisms of disease in neuroendocrine cancer and the brain.

Position open for a lab scientist member to conduct preclinical cellular and molecular neuroscience and cancer research.  This research aims to understand the causes and developing new treatments for mental illness, addiction, neuronal injury, and neuroendocrine cancer. The person awarded this position will conduct experiments using both in vitro and in vivo model systems. Studies will also encompass analysis of patient derived samples. The successful candidate will work with a strong team of basic researchers and physicians study mechanisms that control cellular function and disease progression in cells as well as in vivo models. Effort will be directed at assessments of the efficacy of new treatments and the application of multidisciplinary techniques including pharmacology, biochemistry, cell biology, animal behavior, histology, physiology, and in vivo imaging.  Candidate should have 3-5 years of research experience in this or a related field and experience with biomedical research using rodents.  The successful candidate will be expected to contribute intellectually to this research, derive and present data, and contribute to scientific publications of high impact.  The candidate will also integrate with all members of an outstanding neuroscience and cancer research lab and contribute to its successful operation. The successful candidate will be given the opportunity to work on an independent project that may be developed into a first author publication. This is an exceptional opportunity to for involvement and career development in translational research relevant to biotechnology, biomedicine, and pharmaceutical industry fields.

You may contact us if you have any questions or if you wish you leave a C.V. and cover letter:

Damian Schwartz, Administrative Director for Bibb Lab
Email: dschwartz@uabmc.edu

Position open for a lab scientist member to conduct preclinical cellular and molecular neuroscience and cancer research. 

Project Description: 

Molecular heterogeneity in pancreatic neuroendocrine tumors

The research team is dedicated to decipher hepatobiliary and pancreatic tumor heterogeneity and its impact on tumor progression and chemoresistance. The project linked to the position aims at better understand the mechanisms underlying pancreatic neuroendocrine tumors progression either “natural” or chemo-induced through clonal selection.

 
Project summary:

Well-differentiated pancreatic neuroendocrine tumors (PanNET) present a large spectrum of molecular alterations and clinical behaviors. Tumors may be proliferative (high grade 2 or 3) at diagnostic but more often become aggressive during the course of the disease. Inter-tumor molecular heterogeneity has been well described for G1/G2 tumors but the mechanisms driving tumor progression at the patient level are unknown. In addition to this native tumor progression, chemotherapies participate in the clonal selection. Temozolomide (TMZ) is widely used in advanced PanNET and is associated in a subset of patients with a brutal shift in aggressivity. The mechanism is also unknown, but it was reported in glioblastoma that TMZ could induce an hypermutator phenotype with aggressive features. The research aims to assess intra-tumor spatial and temporal heterogeneity of well differentiated PanNET at multiple levels (genomic / epigenomic / transcriptomic) with an emphasis on chemotherapy-induced clonal selection and understand its role in tumor progression and chemoresistance.


The candidate must have a strong background in bioinformatics and cancer biology with an emphasis on high throughput DNA (mutation/CNV/phylogeny) and methylation analysis. The team includes a senior bioinformatician with extensive experience in high throughput RNA analysis (bulk and single cell) that will help with this part of the project.


This is an amazing opportunity to carry out an integrative multi-omics spatialized analysis of epigenetically driven tumors in a unique team environment with clinician/molecular pathologist/researchers and bioinformaticians!

[1] Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, et al. Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features. Gastroenterology 2018;155:1999-2013.e3. https://doi.org/10.1053/j.gastro.2018.08.033.

[2] Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, et al. Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nat Commun 2018;9:1978. https://doi.org/10.1038/s41467-018-04383-6.

[3] Cros J, Théou-Anton N, Gounant V, Nicolle R, Reyes C, Humez S, et al. Specific genomic alterations in high grade pulmonary neuroendocrine tumours with carcinoid morphology. Neuroendocrinology 2020. https://doi.org/10.1159/000506292.

Send your CV to Jerome.cros@aphp.fr

The research team is dedicated to decipher hepatobiliary and pancreatic tumor heterogeneity and its impact on tumor progression and chemoresistance.