The impact of MEN1, DAXX, ATRX, and PTEN in pancreatic neuroendocrine cancer pathogenesis

Year: 2012
Institution: Dana-Farber Cancer Institute
Country: United States
State: MA
Award Type: NETRF GRANTS 2005-2017
NET Type: Pancreas
Science Type: Basic

General Overview

This proposal seeks to understand the role of ATRX/DAXX/H3.3-mediated chromatin dysregulation in pancreatic neuroendocrine tumors. These studies will identify important mechanisms of genome regulation, potentially transforming our understanding of neuroendocrine tumors with a goal towards the development of new diagnostic markers and possible new methods of intervention.



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