NET-Smart Therapy: A Targeted Prodrug Strategy

Year: 2018
Institution: The Board of Trustees of the Leland Stanford Junior University
Country: United States
State: CA
Award Type: Pilot
NET Type: Pancreas
Science Type: Translational

General Description

Mazur will explore an enzyme (KMT NSD3 or NSD3) in laboratory models of pNETs with genomic alterations in PTEN, MEN1, and ATRX to see if it helps pancreatic NETs. NSD3 may amplify the impact of these alterations, helping to give neuroendocrine cancer cells the “green light” to reproduce and grow.