Mouse model project using forward genetics

David Tuveson, MD, PhD

Year: 2010
Institution: Cancer Research UK
Country: United States
State: NY
Award Type: NETRF GRANTS 2005-2017
NET Type: Gastrointestinal
Science Type: Basic

General Description

This 4-year study will develop nanobody-directed CAR T-cell therapy with various combinatory approaches in laboratory models to kill NET cells. The research will be carried out in collaboration with Dr. Carl June at the University of Pennsylvania, whose work was integrally involved with the approval of CAR T-cell therapy, a personalized, breakthrough immunotherapy for blood cancer. The multipronged approaches will significantly increase the opportunity to develop efficacious NET-specific immunotherapy.