Epigenetic Regulators of Intestinal Endocrine Cells and Carcinoid Tumors*

Qiao Zhou, PhD; Ramesh Shivdasani, MD, PhD

Year: 2017
Institution: Harvard Medical School
Country: United States
State: MA
Award Type: 2017 Awards
NET Type: Gastrointestinal
Science Type: Basic

General Description

This one-year Pilot Project will investigate how pancreatic neuroendocrine tumors (PanNETs) spread to other organs in the body. Kugel and colleagues have found that a protein called SIRT6 plays a role in metastasis in PanNETs, in pre-clinical models. The investigators hypothesize that loss of SIRT6 may affect metastatic progression in PanNETs. To test this, they will block SIRT6 to see if tumor cells grow faster in its absence, which would suggest that SIRT6 may block metastasis. Their findings could inform the pursuit of targeted therapies, which could help stop the spread of PanNETs.