About 7% of NETs occur in the pancreas. Pancreatic NETs are sometimes called pNETs.
WHERE IS THE PANCREAS?
The pancreas is in the upper abdomen behind the stomach. It has two essential functions:
Produce enzymes that break down food in the small intestine (exocrine cells)
Produce hormones that regulate blood sugar, the movement of the gut, and acid production (endocrine cells)
SYMPTOMS OF PNETS
Some pNETs may not cause any signs or symptoms. But pancreatic neuroendocrine tumors may overproduce hormones and cause a range of symptoms, depending on the hormone. Some of the symptoms include:
Diarrhea
Skin rash
Fatigue
Nausea
Hypoglycemia
Abdominal pain
Digestive problems
Gallbladder problems
Weight changes
Jaundice
RISK FACTORS FOR PNETS
Most pNETS do not appear to be inherited but some risk factors can run in families. A few different syndromes can increase a person’s risk of developing pNETs, including:
Multiple endocrine neoplasia type 1 (MEN1)
Von Hippel-Lindau (VHL) disease
Tuberous sclerosis complex
Neurofibromatosis type 1 (NF1)
Having one of these risk factors does not mean you will develop a NET; it simply increases the likelihood.
PNET vs. pancreatic cancer
Pancreatic neuroendocrine cancer is not the same as “pancreatic cancer,” which usually refers to pancreatic adenocarcinoma. Though they occur in the same organ, these are two different types of cancer.