…system is impaired, leading to an hyper-mutator phenotype. If a similar mechanism is present in pNETs, it may represent a strong rationale for the use of immunotherapy. In addition, we…

…liver metastasis, immune evasion, and their convergence on current immunotherapy resistance in pancreatic neuroendocrine tumors (pNETs). Why is this important? The incidence of pNETs has increased steadily over recent decades,…

General Description This study tests the immunotherapy SurVaxM in combination with a somatostatin analog in patients with survivin-expressing NETs. The vaccine targets survivin, a protein that’s often highly expressed in…

…NET cells that can serve as the basis for the exploration of a new immunotherapy to treat pancreatic NETs. What question will the researchers try to answer? In what ways…

…revolution in cancer therapy. However, determining the potential of immunotherapy to be efficacious for patients with NETs necessitates an understanding of the tumor-immune phenotype which today remains unknown. Research Objectives…