Target Neuron-Cancer Interactions in NETs by Non-Invasive Imaging of SV2A

Year: 2020
Institution: The University of Texas Southwestern Medical Center (UT Southwestern)
Country: United States
State: TX
Award Type: Pilot
NET Type: Multiple
Science Type: Translational

General Desription

In this projec,t Dr. Wong will create the mouse models necessary to determine the impact of recently identified mutations in neuroendocrine tumor development. Next Dr. Wong will conduct experiments using his mouse models to identify the cellular pathways that are deregulated as a result of these mutations. Any pathways identified represent potentially new and novel therapeutic targets for treatment of patients with neuroendocrine tumors. The roles of several genes found to be frequently mutated in non-familial pancreatic neuroendocrine cancer are mostly unknown. In this project, Dr. Wong’s laboratory will introduce these mutations specifically in mouse pancreatic cells and study how these mutations might cause neuroendocrine tumors to develop.