Overcoming Resistance to mTOR Inhibition in pancreatic NETs

Year: 2012
Institution: San Francisco (Contracts & Grants), The Regents of the University of California
Country: United States
State: CA
Award Type: NETRF GRANTS 2005-2017
NET Type: Pancreas
Science Type: Translational

General Description

This study tests the immunotherapy SurVaxM in combination with a somatostatin analog in patients with survivin-expressing NETs. The vaccine targets survivin, a protein that’s often highly expressed in lung, intestinal, and pancreatic NETs and associated with aggressive disease because of its ability to prevent tumor cell death. Many patients with incurable brain cancers on SurvaxM have shown better outcomes than would be expected with standard of care alone.