Identify and validate molecular targets for therapy in a newly developed human midgut carcinoid tumor cell line

Lee Ellis, MD

Year: 2006
Institution: University of Texas M.D. Anderson Cancer Center
Country: United States
State: TX
Award Type: NETRF GRANTS 2005-2017
NET Type: Gastrointestinal
Science Type: Basic

General Description

We aim to elucidate the pathways and mechanisms that lead to NE malignancy and to uncover therapeutic vulnerabilities that may be exploited for treatment. We will, therefore, generate a ‘living biobank’ of intestinal carcinoid and pancreatic neuroendocrine tumor (NET) organoids. In conjunction with our biobank efforts, we aim to model carcinoid and pancreatic NETs through genetic engineering of relevant normal organoids. The organoids will be used for genetic, epigenetic, and drug sensitivity analysis. We will, therefore, induce inactivating mutations in a set of NET-associated genes and characterize the molecular and phenotypic consequences of these mutations or sets of mutations. Each of these aims is expected to elucidate mechanisms of NET formation and progression and reveal therapeutic vulnerabilities.

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