Defining Distinct Subtypes of NECs to Predict Therapeutic Vulnerabilities

Carl Gay, MD, PhD

Year: 2021
Institution: MD Anderson Cancer Center
Country: United States
Award Type: 2017 Awards
NET Type: extrapulmonary neuroendocrine small cell cancer
Science Type: Basic

General Description

This Pilot Project aims to develop a laboratory model, whereby neuroendocrine tumors that have spread to the liver will be removed from the patient during surgery and successfully grown in the laboratory. Using precision cut slice technology, the investigators will cut and culture tissue slices from tumor and adjacent healthy tissue in conditions that will maintain their original tissue properties. They will then be able to use this tool to test responses to various drugs. The finding of this study might lead to translational research with the potential to enable the development of personalized medicine for treatment of NETs.