Collaborative Award: Targeting the Alternative Lengthening of Telomere (ALT) pathway in pancreatic NETs

Christopher Heaphy, PhD

Year: 2016
Institution: Johns Hopkins University School of Medicine
Country: United States
State: MD
Award Type: NETRF GRANTS 2005-2017
NET Type: Pancreas
Science Type: Basic

General Description

The status of the immune ‘landscape’ of neuroendocrine tumors before therapy and after modulation by therapy is unknown. The proposed study will analyze reactive T cell subsets including characterization of the regulatory factors limiting effective immune-mediated tumor elimination. This will inform the development of a truly personalized medicine approach capable of inducing tumor regression and durable disease control.